Putnam's health-care analysts and portfolio managers offer their outlooks and perspectives on key aspects of the COVID-19 pandemic.
- Until a safe and effective vaccine is available, we believe the best near-term solutions are effective therapeutic drugs.
- Neutralizing antibodies have the potential to significantly reduce mortality rates, and we expect to see initial clinical trials data over the summer.
- The quantity of available tests is growing, and companies are ramping up capacity.
The vaccine is a long-term solutionA key resource for our in-house research has been the published guidance of Scott Gottlieb, M.D., former U.S. Food and Drug Administration commissioner. We are in agreement with his view that a safe and effective vaccine will not be ready for mass manufacturing in 2020, and perhaps not for two years. As a result, the best near-term solutions are effective therapeutic drugs.
Antivirals: Treating current COVID-19 patients, the first waveOn a much faster track than the vaccine are antivirals – drugs that are used to treat people once they’ve become sick. I expect the initial therapies to provide modest benefits in COVID-19 patients, such as accelerated recovery times and shortened hospitalizations. According to news releases, the first study in China for one of these antiviral treatments in severe COVID-19 patients did not show a benefit. While more recent data indicate that it may improve time to recovery by approximately 30%, other datasets have been more mixed. It appears this treatment is unlikely to bend the curve enough to allow us to meaningfully reduce social distancing measures. The first large randomized study for another treatment reported mixed results and may only be modestly effective in critically ill COVID-19 patients. There are several studies yet to report through May, and while some may have the potential to help mild to moderate COVID-19 patients, there may be insufficient supply to treat such a large patient population.
Experimental antibody treatments are being used for some of the most severe cases of COVID-19. With this process, blood and serum are taken from patients who have recovered from COVID-19. It is then purified, and the antibodies — which prevent the virus from replicating — are extracted and infused into COVID-19 patients.
We believe neutralizing antibodies have the potential to significantly reduce mortality rates. In our view, one company is in the lead for developing an effective treatment by manufacturing select neutralizing antibodies from recovered COVID-19 patients. The company plans to begin clinical trials in June, and we expect to see initial data over the summer.
The supply/demand challengeThese therapies could reduce mortality and the severity of the disease, allowing patients to leave hospitals sooner. However, because they cannot be administered in an outpatient setting, or at sufficient scale, hospitals will continue to be burdened with COVID-19 caseloads. In the short term, there is still a mismatch of supply and demand, and equipment shortages continue to be a challenge.
William C. Rives, CFA Portfolio Manager, Analyst
Testing: The big challenge is logisticsThe science of creating tests for COVID-19 is not nearly as complex or difficult as developing a vaccine. The technology and capacity to develop tests is in place, but the bigger hurdle today is getting a system in place to conduct mass testing. We do not yet have a central organization directing these efforts, but several effective tests are approved and should become available for everyone who needs them.
The science of creating tests for COVID-19 is not nearly as complex or difficult as developing a vaccine.
Who has the virus and who has recovered?There are two methods of testing for COVID-19. The PCR test is a molecular test designed to identify viral loads and determine if a person currently has the virus. This is the test we've heard about most in the news, and it has largely been limited to people who are coming into hospitals with symptoms. Many PCR tests are already approved for use, and there is significant manufacturing capacity.
The second type of test, the serological test, looks for antibodies in the blood to detect an immune response and determine if a person has already had the virus. Progress in this area is slightly behind that of PCR testing, as work continues to determine the accuracy of these tests.
Speed of PCR results and production are improvingThe speed of results and scale of availability continue to increase. Today, there are point-of-care tests available that can produce results in under an hour and potentially in just 15 minutes. Hospital-based PCR tests are being developed with turnaround times of two to four hours. One company received FDA authorization to send an at-home PCR test and will begin shipping to consumers in the coming weeks. At the same time, the quantity of available tests is growing, and five of the larger biotech companies are ramping up capacity, each producing at least one million tests per week.
Within a few months, we believe testing should be much more widespread. Quicker tests will likely be used for health-care workers and at-risk populations, while the higher throughput tests will be used for the general population. In the past week in the United States, an average of 225,000 tests per day were conducted, and this will continue to increase. By June, we may see as many as 500,000 conducted each day.
Testing is key to easing restrictionsTesting results should help authorities determine how aggressively to ease quarantine restrictions and reopen businesses and communities while vaccine development continues. Those who have recovered from COVID-19 and developed immunity may be able to get back into the workforce sooner. As infections decline and stay-at-home orders are lifted, we are likely to see widespread testing to detect immediately when new clusters of infections emerge. In these areas, measures such as social distancing can be quickly reintroduced to slow the spread. As a result of improved testing, hospitals will be less overwhelmed and patient outcomes should improve considerably.
Testing will play a slightly different, but just as important, role over the longer term. I believe that testing and monitoring of the population will become a permanent part of our new normal. The goal will be to put comprehensive testing procedures in place to prepare for — and ideally prevent — future outbreaks of COVID-19 as well as other viruses.
Michael J. Maguire, CFA Portfolio Manager, Analyst
The challenges aheadAmong the most frustrating aspects of this crisis is the fact that an "all clear" for COVID-19 depends on a comprehensive vaccination program that is effective and safe. Since this solution is at least one year away, if not two or more, we need to assume for the time being that it does not exist as we try to plan for reopening economies and businesses.
On the positive side, if we achieve sufficient hospital capacity, fulfill equipment needs, and create a better mechanism for catching patients earlier in the viral load, we will manage COVID-19 more effectively. If we encounter another wave of infections in the fall, I would be surprised if the mortality rates are anywhere near the levels we have seen with this first wave. In this scenario, a second wave might be considered a non-event by equity markets.
Investment considerationsAs investors, of course, we are researching the risks and opportunities resulting from this global pandemic. While the human toll is devastating, businesses are responding. Many recent top-performing stocks represent companies that are creating tests, as well as the suppliers to those companies. These businesses should continue to benefit as the number of diagnostic tests conducted globally will be sustainably higher than in the past. We are also likely to see increased spending on medical research, particularly in the area of infectious diseases. This will be beneficial for life sciences companies.
As investors, we are researching the opportunities resulting from this crisis, including companies that are creating tests and the suppliers to those companies.Companies that we believe will be negatively affected are those with leverage and those with elective procedure risk — the cancellations of any procedures that are not considered critical, such as orthopedic surgeries or dental appointments. Since we have entered a recessionary environment, this elective procedure risk could be with us for some time. In our opinion, the most vulnerable are the hospitals themselves, which operate with financial leverage and will be under significant pricing pressure due largely to much fewer elective procedures.
For informational purposes only. Not an investment recommendation.
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